---
title: Network Comparability to Known Interactions
slug: network-comparability-to-known-interactions
createdAt: 2026-04-27T14:12:54.536Z
---

To ensure that the networks represent known functions and interactions, we compared the DINA-identified edges with known interactions within the STRING database (version 11.5) ([1](docId\:ympLyKBAU_lbSifdLVGsW)). The known gene interactions in Homo sapiens with a minimum interaction score of 400 were identified, including the gene background of the DINA network being analyzed. Fisher’s exact test was then performed to test whether the gene interactions in STRING were significantly enriched within the Mavatar Discovery DINA network. A significant enrichment of STRING interactions was found in each of the analyzed networks, as described under [Network Distribution and Modularity Analyses](docId:7AxSa9sH8qlRhMTKp8iMm) (p \< 0.001).

# References

1. D. Szklarczyk, R. Kirsch, M. Koutrouli, K. Nastou, F. Mehryary, R. Hachilif, A. L. Gable, T. Fang, N. T. Doncheva, S. Pyysalo, P. Bork, L. J. Jensen, C. Von Mering, The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51, D638–D646 (2023). ([https://doi.org/doi:10.18129/B9.bioc.STRINGdb](https://doi.org/doi:10.18129/B9.bioc.STRINGdb))