---
title: Network Version Information
slug: network-version-information
createdAt: 2026-01-20T12:30:23.279Z
---

This page tracks version history for Mavatar Discovery's DINA (tissue- and disease-specific) networks, including changes to network construction methodology. 

# Version 2

| **Topic**                     | **Version 1**                                                                                                                                                                                     | **Version 2**                                                                                                                                                                                                                                                                                           |
| ----------------------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Edge filtering                | Not applied                                                                                                                                                                                       | Edges included only where confidence based normalized T is higher than the median normalized T across all edges. If the median confidence-based score is 0 then all zero values are discarded. Thereafter, median/zero filtering Benjamini–Hochberg adjusted p ≤ 0.05 filtering is applied.<br /><br /> |
| K nearest neighbors           | Based on the top 20 neighbors (see Edge prioritization below) , while additionally ensuring that each protein coding gene has at least K other protein coding neighbors, or maximum 40 neighbors. | Based on the top 50 neighbors, irrespective of gene type.                                                                                                                                                                                                                                               |
| Edge prioritization           | Based on raw (non-adjusted) T values, evaluated over the full correlation vector.                                                                                                                 | Based on a confidence-bound score derived from normalized T values, evaluated over the pool of edges passing the two filtering steps above.                                                                                                                                                             |
| Edge list orientation impact  | The neighbors were prioritized per gene, after which duplicated edges (i.e. where two genes prioritized each other) were reduced to only one edge per gene pair                                   | The K nearest neighbors are prioritized for the genes in alphabetical order, ensuring unique edge identification for each gene.    <br />                                                                                                                                                               |

# Version 1

Implementation of DINA, tissue- and disease-specific networks. These networks were constructed based on our standard correlation method, as well as our AI – AutoEncoder method. See [Data Collection and Pre-Processing](docId\:aQWp0R_sg1OpIWVVLTcbU), [DINA Network Construction](docId:-4qGal9KYaTnpNNIsLMfc), and [Mavatar Discovery Tools – Scientific Background](docId\:hDJdzxJhReo_hlRFZgYxH) for detailed descriptions of our approach.