Version Information

version 1 implementation of dina, tissue and disease specific networks these networks were constructed based on our standard correlation method, as well as our ai – autoencoder method see data collection and pre processing docid\ aqwp0r sg1opiwvvltcbu , dina network construction docid 4qgal9kyatnpnnislmfc , and mavatar discovery tools – scientific background docid\ hdjdzxjhreo hlrfzgyxh for detailed descriptions of our approach network data inclusion overlap some datasets and samples are expected to overlap between different networks, which may affect interpretations from comparative network analyses in table 1, the proportional overlap between each network pair is presented table 1 percentage of overlapping datasets and samples between dina networks within the mavatar discovery platform network pairs not included in the table contain no overlapping samples; by november 2025 release network 1 network 2 % shared dataset id % shared sample id blood – general blood ai – general 95 12 98 97 breast – breast cancer / tissue breast ai – breast cancer / tissue 94 57 97 89 large intestine – colorectal neoplasms large intestine – rectal neoplasms 94 12 96 61 blood – covid 19 blood – pneumonia 89 29 95 05 small intestine – crohn’s disease small intestine – inflammatory bowel disease 94 44 86 02 lung – general (+pseudobulk) lung – general 76 59 85 24 blood – leukemia blood – myeloid leukemia 67 74 63 34 large intestine – inflammatory bowel disease large intestine – ulcerative colitis 68 75 55 75 large intestine – crohn’s disease large intestine – inflammatory bowel disease 50 00 41 71 blood – leukemia blood – neoplasms 48 44 40 47 lung – mouse general lung – general 35 49 30 56 large intestine – ulcerative colitis gastrointestinal ai – ulcerative colitis 26 19 29 03 small intestine – inflammatory bowel disease small intestine – general 16 51 28 42 lung – mouse general lung – general (+pseudobulk) 28 52 27 36 large intestine – inflammatory bowel disease large intestine – general 12 50 25 86 blood – myeloid leukemia blood – neoplasms 32 81 25 63 small intestine – crohn’s disease small intestine – general 15 60 24 45 large intestine – inflammatory bowel disease gastrointestinal ai – ulcerative colitis 21 15 24 08 liver – mouse general liver – general 24 70 15 33 large intestine – ulcerative colitis large intestine – general 8 59 14 02 large intestine – general gastrointestinal ai – ulcerative colitis 6 30 11 82 large intestine – crohn’s disease large intestine – general 6 25 11 26 bone marrow – leukemia bone marrow – general 4 81 11 17 skin – psoriasis skin – general 8 68 8 90 large intestine – colorectal neoplasms large intestine – general 6 23 6 70 large intestine – rectal neoplasms large intestine – general 5 84 6 45 multi tissue – macrophages and monocytes pbmc – general 4 18 6 13 large intestine – crohn’s disease large intestine – ulcerative colitis 26 67 5 81 lung – neoplasms lung – general 3 02 5 62 lung – neoplasms lung – general (+pseudobulk) 2 67 5 51 multi tissue – cd4+ t cells (+pseudobulk) pbmc – general 6 48 5 11 multi tissue – cd8+ t cells (+pseudobulk) pbmc – general 7 62 4 97 bone marrow – general multi tissue – macrophages and monocytes 5 26 4 31 large intestine – crohn’s disease gastrointestinal ai – ulcerative colitis 9 30 3 25 blood – neoplasms blood – general 3 95 2 40 blood – neoplasms blood ai – general 3 75 2 37 multi tissue – dendritic cells multi tissue – macrophages and monocytes 3 44 2 32 multi tissue – fibroblasts skin – general 3 06 2 25 small intestine – inflammatory bowel disease gastrointestinal ai – ulcerative colitis 8 89 2 13 blood – lupus erythematosus blood ai – general 0 91 1 91 blood – lupus erythematosus blood – general 0 93 1 91 brain – general brain – glioma 3 87 1 76 blood ai – general multi tissue – macrophages and monocytes 3 17 1 62 blood – general multi tissue – macrophages and monocytes 3 25 1 62 blood ai – general multi tissue – cd4+ t cells (+pseudobulk) 2 54 1 35 blood – general multi tissue – cd4+ t cells (+pseudobulk) 2 61 1 35 blood – neoplasms bone marrow – general 1 30 1 34 small intestine – general gastrointestinal ai – ulcerative colitis 2 94 1 32 multi tissue – b cells pbmc – general 2 16 1 32 blood – pneumonia blood ai – general 1 13 0 96 blood – pneumonia blood – general 1 16 0 96 blood – leukemia blood ai – general 1 97 0 96 blood – leukemia blood – general 2 02 0 95 blood – covid 19 blood ai – general 0 98 0 91 blood – covid 19 blood – general 1 01 0 91 blood – covid 19 multi tissue – cd4+ t cells (+pseudobulk) 0 51 0 83 blood – lupus erythematosus multi tissue – cd8+ t cells (+pseudobulk) 0 96 0 82 blood – pneumonia multi tissue – cd4+ t cells (+pseudobulk) 0 50 0 82 blood ai – general multi tissue – b cells 0 88 0 67 blood – general multi tissue – b cells 0 91 0 67 multi tissue – fibroblasts small intestine – crohn’s disease 1 01 0 61 small intestine – crohn’s disease gastrointestinal ai – ulcerative colitis 6 67 0 60 multi tissue – fibroblasts lung – general 1 05 0 60 multi tissue – fibroblasts lung – general (+pseudobulk) 0 94 0 59 multi tissue – fibroblasts small intestine – inflammatory bowel disease 1 00 0 58 blood – neoplasms multi tissue – b cells 0 88 0 55 blood – general multi tissue – cd8+ t cells (+pseudobulk) 1 33 0 53 blood – lupus erythematosus multi tissue – cd4+ t cells (+pseudobulk) 0 53 0 52 multi tissue – dendritic cells pbmc – general 1 28 0 51 blood – myeloid leukemia blood ai – general 1 29 0 51 blood – myeloid leukemia blood – general 1 33 0 51 blood ai – general multi tissue – cd8+ t cells (+pseudobulk) 1 22 0 50 blood – lupus erythematosus multi tissue – macrophages and monocytes 0 31 0 40 multi tissue – fibroblasts small intestine – general 0 52 0 32 multi tissue – cd8+ t cells (+pseudobulk) pancreas – general 0 67 0 27 multi tissue – cd4+ t cells (+pseudobulk) large intestine – rectal neoplasms 0 53 0 25 multi tissue – cd4+ t cells (+pseudobulk) large intestine – colorectal neoplasms 0 53 0 25 multi tissue – fibroblasts large intestine – general 0 30 0 22 blood – lupus erythematosus pbmc – general 0 65 0 21 bone marrow – leukemia multi tissue – cd4+ t cells (+pseudobulk) 0 50 0 21 lung – mouse general multi tissue – macrophages and monocytes 0 60 0 19 multi tissue – cd4+ t cells (+pseudobulk) prostate – general 0 40 0 19 multi tissue – cd8+ t cells (+pseudobulk) skin – general 0 54 0 18 multi tissue – cd8+ t cells (+pseudobulk) lung – general 0 34 0 16 multi tissue – cd8+ t cells (+pseudobulk) lung – general (+pseudobulk) 0 31 0 16 blood – neoplasms pbmc – general 0 50 0 15 multi tissue – fibroblasts lung – mouse general 0 36 0 15 multi tissue – cd8+ t cells (+pseudobulk) small intestine – general 0 51 0 15 blood ai – general bone marrow – general 1 09 0 15 blood – general bone marrow – general 1 12 0 15 multi tissue – cd4+ t cells (+pseudobulk) lung – mouse general 0 27 0 13 blood – myeloid leukemia multi tissue – macrophages and monocytes 0 30 0 13 multi tissue – cd4+ t cells (+pseudobulk) lung – general 0 15 0 13 blood – leukemia multi tissue – macrophages and monocytes 0 29 0 13 multi tissue – cd4+ t cells (+pseudobulk) lung – general (+pseudobulk) 0 14 0 13 breast ai – breast cancer / tissue liver – mouse general 0 12 0 11 breast – breast cancer / tissue liver – mouse general 0 12 0 11 blood – neoplasms multi tissue – macrophages and monocytes 0 27 0 11 lung – general multi tissue – macrophages and monocytes 0 50 0 11 lung – general (+pseudobulk) multi tissue – macrophages and monocytes 0 46 0 11 multi tissue – cd4+ t cells (+pseudobulk) small intestine – general 0 35 0 10 multi tissue – cd4+ t cells (+pseudobulk) large intestine – general 0 23 0 10 bone marrow – general multi tissue – cd4+ t cells (+pseudobulk) 0 29 0 09 liver – mouse general multi tissue – macrophages and monocytes 0 19 0 09 large intestine – general multi tissue – macrophages and monocytes 0 18 0 08 breast ai – breast cancer / tissue multi tissue – cd4+ t cells (+pseudobulk) 0 25 0 07 breast – breast cancer / tissue multi tissue – cd4+ t cells (+pseudobulk) 0 26 0 07 multi tissue – cd4+ t cells (+pseudobulk) skin – general 0 22 0 06 breast ai – breast cancer / tissue multi tissue – fibroblasts 0 14 0 04 breast – breast cancer / tissue multi tissue – fibroblasts 0 15 0 04 blood ai – general breast ai – breast cancer / tissue 0 26 0 04 blood – general breast ai – breast cancer / tissue 0 26 0 04 blood ai – general breast – breast cancer / tissue 0 21 0 04 blood – general breast – breast cancer / tissue 0 21 0 04 large intestine – rectal neoplasms liver – general 0 55 0 03 large intestine – colorectal neoplasms liver – general 0 55 0 03 liver – general multi tissue – macrophages and monocytes 0 10 0 03 blood ai – general multi tissue – dendritic cells 0 07 0 02 blood – general multi tissue – dendritic cells 0 08 0 02